2015 Course Materials

 

Lecture Powerpoint Slides

Handouts and Guides

Problem Sets

 

Video

Textbook Chapters

  1. Snyder & Champness Ch 7
  2. Snyder & Champness Ch 8

Readings

  1. Mullis, Kary B (April 1990)  The Unusual Origin of the Polymerase Chain Reaction.  Scientific American 262: 56-65  (RR)
  2. Crick, FHC (1966)  The Genetic Code: III.  Scientific American 215: 55-62   (RR)
  3. Pham TT, Jacobs-Sera D, Pedulla ML, Hendrix RW, Hatfull GF. (2007) Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria. Microbiology Aug;153(Pt 8): 2711-23
  4. Pope, et. al., (2011) Cluster K mycobacteriophages: insights into the evolutionary origins of mycobacteriophage TM4. Plos One 2011; 6(10):e26750. (RR)
  5. See also Etienne L and Emerman M (2013) The mongoose, the pheasant, the pox, and the retrovirus. PLoS Biology 11: e1001641.
  6. Faruque, SM, MJ Islam, QS Ahmad, ASG Faruque, DA Sack, GB Nair, JJ Mekalanos (2005)  Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.  Proc Natl Acad Sci  USA 102: 6119-6124.
  7. See also Reardon, S (2014) Phage therapy gets revitalized. Nature 510: 15-16.

References

Webber, C and Ponting, C P (2004)  Genes and homology.  Curr Biol 14: R332-3.

Pedulla, M et al (2003)  Origins of highly mosaic mycobacteriophage genomes.  Cell 113: 171-182

Hatfull, GF, ….RW Hendrix (2006) Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform. PLoS 2: e92.

Hatfull, GF, SG Cresawn, RW Hendrix (2008) Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution.  Res. Microbiol. 159: 332-339.  (RR)

Hatfull, GF (2014) Molecular Genetics of Mycobacteriophages. Microbiol Spectr 2: 1-36.

Pope, et. al., (2011) Expanding the diversity of mycobacteriophages: Insights into genome architecture and evolution. Plos One 2011 Jan 27;6(1).

Jacobs-Sera, D, et al. (2012) On the nature of mycobacteriophage diversity and host preference. Virology 434: 187-201.

Stern AM, A Casadevall, RG Steen, FC Fang (2014) Financial costs and personal consequences of research misconduct resulting in retracted publications. eLife 3:e02956. DOI: 10.7554/eLife.02956

Hu JC (2014) Why do scientists commit fraud? http://www.slate.com/articles/health_and_science/science/2014/08/fraud_in_stem_cell_research_japanese_biologist_yoshiki_sasai_commits_suicide.html

Websites

Natural Sciences Learning Center
Washington University - Biology
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